Kynurenine Monooxygenase (KMO) Inhibitors for the Treatment of Acute Pancreatitis and Neurodegenerative Disorders

Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase

Kynurenine-3-monooxygenase (KMO) is a key FAD-dependent enzyme of tryptophan metabolism. In animal models, KMO inhibition has shown benefit in neurodegenerative diseases such as Huntington's and Alzheimer's. Most recently it has been identified as a target for acute pancreatitis multiple organ dysfunction syndrome (AP-MODS); a devastating inflammatory condition with a mortality rate in excess o...

New Hopes and Challenges for Treatment of Neurodegenerative Disorders: Great Opportunities for Young Neuroscientists

hdac inhibitors in neurodegenerative disorders

neurodegenerative disorders such as huntingtons disease, alzheimers disease, parkinsons disease, amyotrophic lateral sclerosis, spinal muscular atrophy, friedreichs ataxia, and others are multi-factorial illnesses in which many pathways (still poorly understood) act serially and in parallel to give a determined pathologic phenotype. thus, presently there are no effective cures for these disease...

comparison of zoe and vitapex for canal treatment of necrotic primary teeth

چکیده ندارد.

Effect of Diclofenac Suppository on Treatment of Acute Biliary Pancreatitis

Background and Aim: Acute pancreatitis is an inflammatory pancreatic disease that is associated with low or no fibrosis of the pancreas. Standard non-surgical treatment in all patients involves correcting water and electrolyte disorders, pain relief and avoiding pancreatic secretion. Given that pancreatitis is an inflammatory process, and NSAIDs have been shown to modulate inflammatory processe...